Are there different types of Epidermolysis bullosa?

The are 30 subtypes of the disease. The differences in the subtypes depend on which protein is absent or not functioning and which layer of the skin is affected. Each type of EB has different characteristics and symptoms and these different types can be grouped into 3 main types.

[siteorigin_widget class=”SiteOrigin_Widget_Image_Widget”][/siteorigin_widget]


Simplex EB


Wounds and blistering occurs on the epidermis, the surface layer of the skin. People affected with this type usually show some improvement over time.

[siteorigin_widget class=”SiteOrigin_Widget_Image_Widget”][/siteorigin_widget]


Junctural EB


The blistering occurs between the external layer (the epidermis) and the internal layer (the dermis). The subtypes included in this group range from lethal at birth to other less severe types, which show some improvement over time. This is the rarest form.

[siteorigin_widget class=”SiteOrigin_Widget_Image_Widget”][/siteorigin_widget]


Dystrophic EB


Blistering occurs in the lowest layer of the skin, the dermis. As the wounds heal, the skin tightens and retracts affecting the use of both hands and feet and with this movement in general. Blistering also occurs in the mouth, eyes, pharynx, stomach, intestine, respiratory ways and urinary tracts.


For further more detailed information on the characteristics and symptoms of the disease please refer to our frequent asked questions page here.